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Global Life Sciences Fund Holdings

Full Portfolio Holdings

(As of 12/31/2025)

% OF INVESTMENTS
Eli Lilly & Co 9.66
Johnson & Johnson 5.58
AstraZeneca PLC 4.26
UnitedHealth Group Inc 3.43
AbbVie Inc 3.38
Abbott Laboratories 2.64
Argenx SE (ADR) 2.62
Novartis AG (ADR) 2.49
Praxis Precision Medicines Inc 2.38
Boston Scientific Corp 2.35
Intuitive Surgical Inc 2.31
Thermo Fisher Scientific Inc 2.30
Sanofi SA 2.29
Amgen Inc 2.15
Roche Holding AG 2.13
Bridgebio Pharma Inc 2.11
Vertex Pharmaceuticals Inc 2.04
HCA Healthcare Inc 1.96
REVOLUTION Medicines Inc 1.93
Danaher Corp 1.78
Stryker Corp 1.64
CVS Health Corp 1.52
Ascendis Pharma A/S (ADR) 1.50
Madrigal Pharmaceuticals Inc 1.43
McKesson Corp 1.28
Globus Medical Inc 1.23
Teva Pharmaceutical Industries Ltd (ADR) 1.19
Medtronic PLC 1.16
Elevance Health Inc 1.11
Gilead Sciences Inc 1.10
PTC Therapeutics Inc 1.09
Travere Therapeutics Inc 1.03
Cencora Inc 1.02
Mirum Pharmaceuticals Inc 1.01
Avidity Biosciences Inc 0.99
United Therapeutics Corp 0.97
Dyne Therapeutics Inc 0.92
Soleno Therapeutics Inc 0.87
Vaxcyte Inc 0.84
Structure Therapeutics Inc (ADR) 0.75
Edwards Lifesciences Corp 0.74
Medline Inc 0.69
UCB SA 0.68
Daiichi Sankyo Co Ltd 0.66
Lantheus Holdings Inc 0.65
Becton Dickinson & Co 0.61
Penumbra Inc 0.58
Apogee Therapeutics Inc 0.53
DexCom Inc 0.53
Ideaya Biosciences Inc 0.49
Cooper Cos Inc 0.49
Glaukos Corp 0.46
Tarsus Pharmaceuticals Inc 0.42
STERIS PLC 0.39
Rhythm Pharmaceuticals Inc 0.38
Neurocrine Biosciences Inc 0.37
Heartflow Inc 0.36
Nuvalent Inc 0.35
Sotera Health Co 0.35
Regeneron Pharmaceuticals Inc 0.35
Alnylam Pharmaceuticals Inc 0.34
Ardelyx Inc 0.34
Zoetis Inc 0.32
Olema Pharmaceuticals Inc 0.31
Edgewise Therapeutics Inc 0.29
Scholar Rock Holding Corp 0.28
Cogent Biosciences Inc 0.27
Xenon Pharmaceuticals Inc 0.26
Insmed Inc 0.26
Centene Corp 0.26
Crinetics Pharmaceuticals Inc 0.26
Protagonist Therapeutics Inc 0.26
Terns Pharmaceuticals Inc 0.26
Humana Inc 0.25
Inspire Medical Systems Inc 0.25
Illumina Inc 0.25
Arcellx Inc 0.25
Teleflex Inc 0.23
KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD 0.23
Insulet Corp 0.19
Avadel Pharmaceuticals PLC 0.19
Janux Therapeutics Inc 0.19
Immunome Inc 0.15
4D Molecular Therapeutics Inc 0.12
Lexeo Therapeutics Inc 0.12
Curevo Inc 0.10
KARDIUM SERIES 8 CLASS D PREFERRED SHARES USD 0.07
Loadsmart Inc 0.07
Magnolia Medical Technologies Inc 0.06
Element Biosciences Inc 0.05
Green Cross Holdings Corp 0.04
Sonoma Biotherapeutics Inc 0.04
PFIZER INC 0.04
Twinstrand Biosciences Inc 0.03
Sonoma Biotherapeutics Inc 0.02
Freenome Holdings Inc 0.02
Freenome Holdings Inc 0.02
Asher Biotherapeutics Inc 0.02
Attralus Inc 0.01
Hemoshear Therapeutics LLC 0.01
Heartflow Inc 0.01
Asher Biotherapeutics Inc 0.01
Novo Nordisk A/S 0.01
Cash & Equivalents 0.72
Janus Henderson publishes this listing of securities held as of the most recently available disclosure period, which varies depending on the portfolio. Any portion of holdings may be excluded from publication when deemed in the best interest of the portfolio. Securities are reported at market value.
The portfolio data and its presentation here is based on the investment book of record and may differ from the accounting book of record and complete schedules of investments in regulatory filings due to differing accounting and reporting standards.