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Global Life Sciences: long-term tailwinds in focus Copy


5 Jul 2018
In this outlook video, Ethan Lovell, Co-Portfolio Manager for the Janus Henderson Global Life Sciences Fund​, explains that scrutiny over drug costs has led to recent volatility in healthcare stocks. The longer-term picture, however, is very encouraging with the sector making dramatic leaps in advanced medicines such as immunotherapy, which provides potentially significant market opportunities. Ethan answers:
  • What has been driving volatility in the healthcare sector recently?
  • What long-term tailwinds do you see benefiting the healthcare sector?
  • What innovations are you most excited about this year in healthcare?

Glossary:

Biosimilar – a biopharmaceutical drug designed with properties that are almost identical to a previously licensed drug manufactured by a different company. These products function in a similar way to the original drug.   CMS – Centers for Medicare & Medicaid Services. EBITDA – earnings before interest, taxes, depreciation, and amortisation. This is an accounting measure used as a proxy for a company’s current operating profitability.   EMEA – European Medicines Evaluation Agency.   Immuno-oncology – an approach to cancer treatment whereby an individual’s immune system is harnessed and used to attack cancer cells in the body.   Pharmacy benefit manager (PBM) – a third-party administrator of prescription drug programmes.

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Janus Henderson Global Life Sciences Fund

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Specific risks

  • The Fund endeavours to reduce risk by investing in a range of companies and sub-sectors of the life sciences industry. However, the Fund may be less diversified than other investment products and suffer proportionately higher loss should a particular investment decline in value.
  • The Fund may be denominated in a different currency than the share class of your investment. The value of your shares may rise and fall as a result of exchange rate movements between currencies.
  • The Fund may hold investments denominated in currencies other than the base currency of the Fund. Fluctuations in exchange rates may expose the Fund to losses independent of investment performance.
  • The Fund uses specialist financial derivative instruments (FDI) that can multiply gains and losses significantly in excess of the FDI's original cost, thus significantly increasing risk. We aim to reduce this risk by using a robust risk management process that will aim to limit the maximum potential loss. The use of these instruments involves other risks, in particular, counterparty risk, which is the risk to each party to a contract that the other party will not live up to its contractual obligations.
  • The Fund investments are focused on life sciences companies. Changes in government regulation or subsidies, or a change in technology may affect the value of investments in the Fund.
  • The value of investments held in the Fund and the income from them may rise or fall. The Fund may not achieve its investment objectives.
  • Smaller or newer companies are subject to greater risk and reward potential. Investments may be volatile or difficult to buy or sell.


5 Jul 2018

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