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To US Financial Professionals servicing non-US persons

Global Life Sciences Fund

By understanding the science and business of health care, the strategy invests in companies addressing unmet medical needs or improving health care efficiencies

ISIN
IE0002141913

NAV
USD 63.43
As of 12/20/2024

1-Day Change
USD 0.15 (0.24%)
 As of 12/20/2024

Morningstar Rating

As of 11/30/2024

Morningstar Medalist Rating ™

Morningstar Analyst Rating
As of 10/07/2024

Overview

Quarterly update

Watch the investment team recap this quarter.

(Note: Filmed in October 2024).

INVESTMENT OBJECTIVE

The Fund aims to provide capital growth over the long term.
Performance target: To outperform the MSCI World Health Care Index by at least 2% per annum, before the deduction of charges, over any 5 year period.

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The Fund invests at least 80% in shares (also known as equities) of companies, of any size, including smaller capitalisation companies, with a life sciences orientation, in any country. Up to 20% may be invested in developing markets.
The Fund may also invest in other assets including cash and money market instruments.
The Sub-Investment Adviser may use derivatives (complex financial instruments) to reduce risk, to manage the Fund more efficiently, or to generate additional capital or income for the Fund.
The Fund is actively managed with reference to the MSCI World Health Care Index, which is broadly representative of the companies in which it may invest, as this forms the basis of the Fund's performance target. The Sub-Investment Adviser has discretion to choose individual investments for the Fund with weightings different to the index or not in the index, but at times the Fund may hold investments similar to the index.

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The value of an investment and the income from it can fall as well as rise as a result of market and currency fluctuations and you may not get back the amount originally invested.
Potential investors must read the prospectus, and where relevant, the key investor information document before investing.
This website is a Marketing Communication and does not qualify as an investment recommendation.

ABOUT THIS FUND

  • Looks to invest in companies addressing unmet medical needs or those that seek to make the health care system more efficient
  • Aims to maintain a balanced portfolio across subsectors (biotechnology, health care services, medical devices and pharmaceuticals)
  • An experienced team of specialists that seeks to understand the science and the business of health care
Past performance does not predict future returns. 
 

Portfolio Management

Andy Acker, CFA
Andy Acker, CFA

Portfolio Manager

Industry since 1996. Joined Firm in 1999.

Daniel Lyons, Ph.D., CFA
Daniel Lyons, Ph.D., CFA

Portfolio Manager | Research Analyst

Industry since 2000. Joined Firm in 2000.

Performance

Past performance does not predict future returns. All performance data includes both income and capital gains or losses and reflects the deduction of any ongoing charges or other fund expenses.
Cumulative & Annualised Performance (%)
As of 11/30/2024
I2 USD (Net) MSCI World Health Care NR Sector Equity Healthcare - OE
  
  Cumulative Annualised
1MO YTD 1YR 3YR 5YR 10YR Since Inception
03/31/2000
I2 USD (Net) -0.74 11.02 19.33 6.65 9.23 8.39 8.11
MSCI World Health Care NR -0.87 7.68 12.45 4.30 8.24 7.73 7.58
Sector Equity Healthcare - OE 0.18 4.83 10.85 -1.13 4.29 4.93 6.06
 
  Annualised
3YR 5YR 10YR Since Inception
03/31/2000
I2 USD (Gross) - 10.94 10.14 9.92
MSCI World Health Care NR + 2.00% - 10.41 9.89 9.73
Note that any differences among portfolio securities currencies, share class currencies and costs to be paid or represented in currencies other than your home currency will expose you to currency risk.  Costs and returns may increase or decrease as a result of currency and exchange rate fluctuations.
Performance/performance target related data will display only when relevant to the fund/share class inception date and the annualised target time period.
© Morningstar 2024. All rights reserved. NAV-NAV, gross income reinvested where applicable.
Fund charges will impact the value of your investment. In particular, the ongoing charges applicable to each fund will dilute investment performance, particularly over time.
Calendar Year Returns (%)
I2 USD (Net) MSCI World Health Care NR Sector Equity Healthcare - OE
YTD 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014
I2 USD (Net) 15.73 6.32 -3.59 5.60 24.37 28.04 2.76 21.48 -13.17 6.55 33.68
MSCI World Health Care NR 14.14 3.76 -5.41 19.80 13.52 23.24 2.51 19.80 -6.81 6.60 18.10
Sector Equity Healthcare - OE 10.07 2.67 -13.91 7.12 20.53 21.80 -3.40 21.68 -9.37 5.90 18.33
Calendar Year Returns (%)
Year I2 USD (Net) Index
2023 6.32 3.76
2022 -3.59 -5.41
2021 5.60 19.80
2020 24.37 13.52
2019 28.04 23.24
2018 2.76 2.51
2017 21.48 19.80
2016 -13.17 -6.81
2015 6.55 6.60
2014 33.68 18.10
2013 53.88 36.27
2012 23.73 17.54
2011 7.03 9.46
2010 7.16 2.41
2009 25.68 18.89
2008 -30.45 -21.50
2007 20.78 3.94
2006 -2.90 10.47
2005 10.80 9.00
2004 13.33 6.00
2003 26.73 19.50
2002 -30.67 -17.98
2001 -20.02 -13.24
2000 from 31/03/2000 17.40 25.65
Note that any differences among portfolio securities currencies, share class currencies and costs to be paid or represented in currencies other than your home currency will expose you to currency risk.  Costs and returns may increase or decrease as a result of currency and exchange rate fluctuations.
Performance/performance target related data will display only when relevant to the fund/share class inception date and the annualised target time period.
© Morningstar 2024. All rights reserved. NAV-NAV, gross income reinvested where applicable.
Fund charges will impact the value of your investment. In particular, the ongoing charges applicable to each fund will dilute investment performance, particularly over time.
Please note the performance target is to be achieved over a specific annualised time period. Refer to the performance target wording within the objective.

Recommended holding period 5 Years

Example Investment: USD 10,000

Scenarios If you exit after 1 year If you exit after 5 years
MinimumThere is no minimum guaranteed return. You could lose some or all of your investment
StressWhat you might get back after costs1,400 USD1,460 USD
Average return each year-86.02%-31.94%
UnfavourableWhat you might get back after costs7,930 USD10,490 USD
Average return each year-20.71%0.97%
ModerateWhat you might get back after costs10,900 USD15,700 USD
Average return each year8.98%9.44%
FavourableWhat you might get back after costs14,190 USD20,920 USD
Average return each year41.93%15.90%
This chart shows the fund’s performance as the percentage loss or gain per year over the last 10 years against its benchmark. It can help you to assess how the fund has been managed in the past and compare it to its benchmark.

As of 09/30/2024
I2 USD (Net) MSCI World Health Care NR Sector Equity Healthcare - OE
Note that any differences among portfolio securities currencies, share class currencies and costs to be paid or represented in currencies other than your home currency will expose you to currency risk.  Costs and returns may increase or decrease as a result of currency and exchange rate fluctuations.
Past performance does not predict future returns. The value of an investment may go down as well as up and you may lose the amount originally invested. Markets could develop very differently in the future. It can help you to assess how the fund has been managed in the past.
© Morningstar 2024. All rights reserved. NAV-NAV, gross income reinvested where applicable.
Fund charges will impact the value of your investment. In particular, the ongoing charges applicable to each fund will dilute investment performance, particularly over time.
Annual Fees & Expenses (As of the most recent prospectus)
Initial Charge 2.00%
Annual Charge 1.50%
Ongoing Charge
(As of 12/31/2023) 		1.56%
The ongoing charge is calculated using the PRIIPs methodology. The PRIIPs methodology differs to the UCITS ongoing charge methodology, as the PRIIPS methodology captures additional recurring charges, including but not limited to: a. Interest paid on borrowing (e.g. bank interest) b. Any fees incurred in relation to stock-lending activity (i.e. the fee paid to the lending agent) c. Any costs associated with holding closed-ended vehicles.
For more information about charges, please see our fund charges page or the “charges” section of the fund’s prospectus.

Portfolio

Top Holdings (As of 11/30/2024)
% of Fund
Eli Lilly & Co 8.51
UnitedHealth Group Inc 7.36
Novo Nordisk A/S 4.29
AstraZeneca PLC 3.50
Amgen Inc 3.00
Johnson & Johnson 2.96
Abbott Laboratories 2.67
Boston Scientific Corp 2.65
Vertex Pharmaceuticals Inc 2.53
Sanofi SA 2.52
TOTAL 39.99
References made to individual securities do not constitute a recommendation to buy, sell or hold any security, investment strategy or market sector, and should not be assumed to be profitable. Janus Henderson Investors, its affiliated advisor, or its employees, may have a position in the securities mentioned.
Sector Allocation % of Fund % of Index % of Fund % of Index As of 11/30/2024
Regional Allocation % of Fund % of Index % of Fund % of Index As of November 30, 2024

Documents

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  • The value of the Funds and the income from them is not guaranteed and may fall as well as rise. You may get back less than you originally invested.
  • Past performance does not predict future returns.
  • Third party data is believed to be reliable, but its completeness and accuracy is not guaranteed.
  • Shares/Units can lose value rapidly, and typically involve higher risks than bonds or money market instruments. The value of your investment may fall as a result.
  • Shares of small and mid-size companies can be more volatile than shares of larger companies, and at times it may be difficult to value or to sell shares at desired times and prices, increasing the risk of losses.
  • If a Fund has a high exposure to a particular country or geographical region it carries a higher level of risk than a Fund which is more broadly diversified.
  • The Fund is focused towards particular industries or investment themes and may be heavily impacted by factors such as changes in government regulation, increased price competition, technological advancements and other adverse events.
  • The Fund may use derivatives to help achieve its investment objective. This can result in leverage (higher levels of debt), which can magnify an investment outcome. Gains or losses to the Fund may therefore be greater than the cost of the derivative. Derivatives also introduce other risks, in particular, that a derivative counterparty may not meet its contractual obligations.
  • If the Fund holds assets in currencies other than the base currency of the Fund, or you invest in a share/unit class of a different currency to the Fund (unless hedged, i.e. mitigated by taking an offsetting position in a related security), the value of your investment may be impacted by changes in exchange rates.
  • When the Fund, or a share/unit class, seeks to mitigate exchange rate movements of a currency relative to the base currency (hedge), the hedging strategy itself may positively or negatively impact the value of the Fund due to differences in short-term interest rates between the currencies.
  • Securities within the Fund could become hard to value or to sell at a desired time and price, especially in extreme market conditions when asset prices may be falling, increasing the risk of investment losses.
  • The Fund could lose money if a counterparty with which the Fund trades becomes unwilling or unable to meet its obligations, or as a result of failure or delay in operational processes or the failure of a third party provider.
  • Funds incur costs as a necessary part of buying and selling the underlying investments, these are otherwise known as portfolio transaction costs, and include charges such as broker commission and Stamp Duty.
  • Before investing in any of our funds you should satisfy yourself as to the suitability and the risks involved.
  • Summary of Investor rights
  • Janus Henderson Investors Europe S.A. may decide to terminate the marketing arrangements of this Collective Investment Scheme in accordance with the appropriate regulation.
  • Information on compliance with EU Sustainability related disclosures can be found here.
  • For detailed product information including the risks associated with investing please read the relevant Prospectus or Annual Report. Please refer to the prospectus of the UCITS and to the KID before making any final investment decisions.
  • The Legal Entity Identifier for this product is 5493002MVUQOZF2KCA11.

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