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For Institutional Investors in the US

Global Life Sciences Fund Holdings

Full Portfolio Holdings

(As of October 31, 2024)

% OF INVESTMENTS
Eli Lilly & Co 8.63
UnitedHealth Group Inc 6.78
Novo Nordisk A/S 4.46
AbbVie Inc 3.79
AstraZeneca PLC 3.53
Amgen Inc 3.41
Johnson & Johnson 2.80
Sanofi SA 2.66
Boston Scientific Corp 2.58
Vertex Pharmaceuticals Inc 2.46
Abbott Laboratories 2.43
Merck & Co Inc 2.33
Novartis AG (ADR) 2.21
Argenx SE (ADR) 2.17
Thermo Fisher Scientific Inc 1.79
Stryker Corp 1.78
Intuitive Surgical Inc 1.77
Danaher Corp 1.69
Vaxcyte Inc 1.67
Sarepta Therapeutics Inc 1.55
Madrigal Pharmaceuticals Inc 1.27
Roche Holding AG 1.24
HCA Healthcare Inc 1.22
Globus Medical Inc 1.20
Elevance Health Inc 1.15
REVOLUTION Medicines Inc 1.13
Ascendis Pharma A/S (ADR) 1.09
Biohaven Ltd 1.06
United Therapeutics Corp 1.05
Akero Therapeutics Inc 1.01
McKesson Corp 0.87
Teva Pharmaceutical Industries Ltd (ADR) 0.86
Lantheus Holdings Inc 0.83
Soleno Therapeutics Inc 0.82
Avidity Biosciences Inc 0.78
Medtronic PLC 0.77
Zoetis Inc 0.77
Humana Inc 0.76
Dyne Therapeutics Inc 0.75
Penumbra Inc 0.75
Avadel Pharmaceuticals PLC 0.74
Cooper Cos Inc 0.71
Arcellx Inc 0.71
Teleflex Inc 0.68
Cencora Inc 0.67
Edwards Lifesciences Corp 0.61
Zai Lab Ltd (ADR) 0.60
Illumina Inc 0.59
Inspire Medical Systems Inc 0.58
Mirum Pharmaceuticals Inc 0.58
STERIS PLC 0.56
Structure Therapeutics Inc (ADR) 0.53
Ardelyx Inc 0.48
Janux Therapeutics Inc 0.45
Edgewise Therapeutics Inc 0.45
Ideaya Biosciences Inc 0.44
89bio Inc 0.42
Gilead Sciences Inc 0.42
Legend Biotech Corp (ADR) 0.41
Centene Corp 0.40
Alnylam Pharmaceuticals Inc 0.40
Sotera Health Co 0.38
Crinetics Pharmaceuticals Inc 0.38
Hoya Corp 0.37
PTC Therapeutics Inc 0.36
Amicus Therapeutics Inc 0.33
ICON PLC 0.32
Neurocrine Biosciences Inc 0.32
Cytokinetics Inc 0.29
Takeda Pharmaceutical Co Ltd 0.28
DexCom Inc 0.28
Insmed Inc 0.26
NeoGenomics Inc 0.26
Xenon Pharmaceuticals Inc 0.26
Align Technology Inc 0.25
Rhythm Pharmaceuticals Inc 0.24
Bridgebio Pharma Inc 0.22
Neurogene Inc 0.21
IQVIA Holdings Inc 0.21
Perspective Therapeutics Inc 0.20
Royalty Pharma plc 0.20
Cargo Therapeutics Inc 0.19
Bicara Therapeutics Inc 0.19
CG oncology Inc 0.19
Geron Corp 0.18
Immunome Inc 0.17
Rocket Pharmaceuticals Inc 0.16
Bridgebio Pharma Inc 0.15
4D Molecular Therapeutics Inc 0.15
Heartflow Inc 0.11
Curevo Inc 0.10
Lexeo Therapeutics Inc 0.10
Shoreline Biosciences Inc 0.10
Attralus Inc 0.09
Sonoma Biotherapeutics Inc 0.09
Element Biosciences Inc 0.08
Bicara Therapeutics Inc 0.06
Magnolia Medical Technologies Inc 0.05
Asher Biotherapeutics Inc 0.05
Applied Therapeutics Inc 0.05
Sonoma Biotherapeutics Inc 0.05
Freenome Holdings Inc 0.03
Freenome Holdings Inc 0.03
Asher Biotherapeutics Inc 0.03
Twinstrand Biosciences Inc 0.03
Green Cross Holdings Corp 0.02
Magnolia Medical Technologies Inc, 10.00%, 12/31/25 0.01
Magnolia Medical Technologies 0.00
Clementia Pharmaceuticals Inc 0.00
Cash & Equivalents 0.62
Janus Henderson publishes this listing of securities held as of the most recently available disclosure period, which varies depending on the portfolio. Any portion of holdings may be excluded from publication when deemed in the best interest of the portfolio. Securities are reported at market value.
The portfolio data and its presentation here is based on the investment book of record and may differ from the accounting book of record and complete schedules of investments in regulatory filings due to differing accounting and reporting standards.