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For Institutional Investors in the US

Global Life Sciences Fund Holdings

Full Portfolio Holdings

(As of December 31, 2024)

% OF INVESTMENTS
Eli Lilly & Co 8.96
UnitedHealth Group Inc 6.62
Novo Nordisk A/S 3.66
AstraZeneca PLC 3.66
Johnson & Johnson 3.06
Boston Scientific Corp 2.83
Amgen Inc 2.80
Abbott Laboratories 2.75
Sanofi SA 2.72
AbbVie Inc 2.62
Merck & Co Inc 2.45
Vertex Pharmaceuticals Inc 2.37
Argenx SE (ADR) 2.30
Thermo Fisher Scientific Inc 2.28
Novartis AG (ADR) 2.13
Intuitive Surgical Inc 2.00
Danaher Corp 1.89
Stryker Corp 1.80
Sarepta Therapeutics Inc 1.62
Vaxcyte Inc 1.40
Teva Pharmaceutical Industries Ltd (ADR) 1.36
Ascendis Pharma A/S (ADR) 1.33
Globus Medical Inc 1.27
Madrigal Pharmaceuticals Inc 1.23
REVOLUTION Medicines Inc 1.22
Roche Holding AG 1.21
HCA Healthcare Inc 1.18
Elevance Health Inc 1.14
McKesson Corp 1.08
United Therapeutics Corp 1.00
Akero Therapeutics Inc 0.95
Biohaven Ltd 0.91
Soleno Therapeutics Inc 0.88
Lantheus Holdings Inc 0.85
Penumbra Inc 0.84
Humana Inc 0.80
Medtronic PLC 0.77
Zoetis Inc 0.77
Avidity Biosciences Inc 0.76
Edwards Lifesciences Corp 0.74
Cencora Inc 0.72
Dyne Therapeutics Inc 0.70
Cooper Cos Inc 0.67
Mirum Pharmaceuticals Inc 0.66
Inspire Medical Systems Inc 0.63
Janux Therapeutics Inc 0.61
Teleflex Inc 0.60
Illumina Inc 0.59
Avadel Pharmaceuticals PLC 0.56
Arcellx Inc 0.54
Bridgebio Pharma Inc 0.49
Zai Lab Ltd (ADR) 0.48
Gilead Sciences Inc 0.45
Ardelyx Inc 0.45
89bio Inc 0.45
Ideaya Biosciences Inc 0.45
PTC Therapeutics Inc 0.44
Centene Corp 0.41
STERIS PLC 0.40
Edgewise Therapeutics Inc 0.39
Neurocrine Biosciences Inc 0.39
Structure Therapeutics Inc (ADR) 0.39
Alnylam Pharmaceuticals Inc 0.37
Crinetics Pharmaceuticals Inc 0.37
Sotera Health Co 0.35
NeoGenomics Inc 0.34
Hoya Corp 0.34
DexCom Inc 0.34
ICON PLC 0.32
Legend Biotech Corp (ADR) 0.32
Rhythm Pharmaceuticals Inc 0.30
Takeda Pharmaceutical Co Ltd 0.29
Cytokinetics Inc 0.29
Insmed Inc 0.29
Xenon Pharmaceuticals Inc 0.28
Align Technology Inc 0.28
Amicus Therapeutics Inc 0.27
Praxis Precision Medicines Inc 0.23
Geron Corp 0.22
IQVIA Holdings Inc 0.22
Apogee Therapeutics Inc 0.21
Travere Therapeutics Inc 0.20
CG oncology Inc 0.19
Immunome Inc 0.19
Rocket Pharmaceuticals Inc 0.18
Cargo Therapeutics Inc 0.17
Bicara Therapeutics Inc 0.16
Heartflow Inc 0.13
Shoreline Biosciences Inc 0.12
Curevo Inc 0.11
4D Molecular Therapeutics Inc 0.11
Sonoma Biotherapeutics Inc 0.10
Lexeo Therapeutics Inc 0.09
Attralus Inc 0.08
Element Biosciences Inc 0.07
Magnolia Medical Technologies Inc 0.06
Asher Biotherapeutics Inc 0.06
Sonoma Biotherapeutics Inc 0.05
Freenome Holdings Inc 0.04
Freenome Holdings Inc 0.04
Green Cross Holdings Corp 0.04
Asher Biotherapeutics Inc 0.03
Twinstrand Biosciences Inc 0.03
Bicara Therapeutics Inc 0.02
Magnolia Medical Technologies Inc, 10.00%, 12/31/25 0.01
Magnolia Medical Technologies 0.00
Clementia Pharmaceuticals Inc 0.00
Cash & Equivalents 0.41
Janus Henderson publishes this listing of securities held as of the most recently available disclosure period, which varies depending on the portfolio. Any portion of holdings may be excluded from publication when deemed in the best interest of the portfolio. Securities are reported at market value.
The portfolio data and its presentation here is based on the investment book of record and may differ from the accounting book of record and complete schedules of investments in regulatory filings due to differing accounting and reporting standards.